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Description
Phospho-NAK/TBK1 (Ser172) Recombinant Rabbit mAb (S-2481-14)Product Specification Host Rabbit Antigen Phospho NAK TBK1 (Ser172) Synonyms Serine threonine protein kinase TBK1; NF kappa B activating kinase; T2K; TANK binding kinase 1; NAK; TBK1 Immunogen Synthetic Peptide Location Cytoplasm Accession Q9UHD2 Clone Number S 2481 14 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt Predicted Reactivity Xe Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | Phospho-NAK/TBK1 (Ser172) |
| Synonyms | Serine/threonine-protein kinase TBK1; NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1; NAK; TBK1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | Q9UHD2 |
| Clone Number | S-2481-14 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Xe |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000-1:10000 | Hu, Ms, Rt |
| ICC | 1:100 | Hu |
Background
Phospho-NAK/TBK1 (Ser172) protein is a crucial component in cellular signaling pathways. NAK, also known as TBK1, is a serine/threonine kinase that plays a significant role in innate immune responses and NF-κB activation. When phosphorylated at serine 172, it becomes activated and can phosphorylate downstream substrates such as IRF3, leading to the production of type I interferons. This phosphorylation event at Ser172 is essential for its kinase activity and its involvement in antiviral signaling and inflammatory responses. Additionally, TBK1 has been implicated in autophagy regulation through its interaction with other proteins, further highlighting its multifaceted functions in maintaining cellular homeostasis and responding to various stressors.
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