LECT2 Recombinant Rabbit mAb (SDT-2160-33)
SKU: 22991547660

LECT2 Recombinant Rabbit mAb (SDT-2160-33)

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Description

LECT2 Recombinant Rabbit mAb (SDT-2160-33)Product Specification Host Rabbit Antigen LECT2 Synonyms Leukocyte cell derived chemotaxin 2; LECT 2; hLECT2; LECT2 Immunogen Recombinant Protein Clone Number SDT 2160 33 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity No cross reactivity against AFP Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months

Product Specification


Host Rabbit
Antigen LECT2
Synonyms Leukocyte cell-derived chemotaxin-2; LECT-2; hLECT2; LECT2
Immunogen Recombinant Protein
Clone Number SDT-2160-33
Antibody Type Recombinant mAb
Isotype IgG
Application Sandwich ELISA
Reactivity Hu
Cross Reactivity

No cross-reactivity against AFP

Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt, 2 to 8 °C as supplied

Background

Leukocyte cell-derived chemotaxin-2 (LECT2) is a 16-kDa secreted hepatic protein belonging to the M23 peptidase family that was first identified as a neutrophil chemoattractant but is now recognized as a multifunctional regulator of immunity, metabolism and tissue remodeling: produced chiefly by hepatocytes and released into the circulation, LECT2 modulates natural killer T-cell homeostasis in the liver, promotes chondrocyte and osteoblast proliferation, orchestrates inflammatory responses by inducing adhesion molecules and pro-inflammatory cytokines in endothelial cells, serves as a hepatokine linking obesity and fatty-liver–associated insulin resistance, exerts antiviral effects via the MET proto-oncogene, and when misfolded forms amyloid fibrils that cause LECT2 amyloidosis primarily affecting kidneys and liver; its expression spans liver, neurons, epithelia and leukocytes, its structure is stabilized by zinc binding and three disulfide bonds, and its dysregulation has been implicated in non-alcoholic steatohepatitis, rheumatoid arthritis, hepatocellular carcinoma and systemic amyloidosis, making it an emerging biomarker and therapeutic target across metabolic, inflammatory and neoplastic diseases.

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SKU: 22991547660

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