Nicotinamide Riboside + Pterostilbene - 30 capsules

Nicotinamide riboside (NR), an advanced form of vitamin B3 (niacin), has proven to be one of the most promising supplements to promote longevity and healthy aging. By functioning as an NAD+ precursor, NR has been proven to significantly increase NAD+ levels in the body, thus promoting heart, brain, metabolic, and cellular health. Pterostilbene is a powerful antioxidant compound that has been shown to activate sirtuins (longevity genes), amplifying the longevity-promoting effects of NR.

NR + Pterostilbene

• Supports longevity by increasing NAD+ levels and activating sirtuins
• Enhances cellular health by promoting DNA repair and reducing oxidative stress
• Promotes heart health by supporting healthy blood flow
• Protects the brain from age-related functional decline

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Research-Supported Benefits:

Promotes Longevity. Nicotinamide Riboside promotes longevity by increasing levels of NAD+ in the body. NAD+ levels decline with age, contributing to accelerated cellular aging and health decline. Research shows that increasing NAD+ levels in aged animals extends lifespan. (1) Pterostilbene supports longevity by activating sirtuins, which are commonly referred to as "longevity genes". Animal studies show that activating sirtuins extends lifespan and healthspan. (2)

Supports Cellular Health. By increasing NAD+ levels, NR aids in facilitating DNA repair. (3) DNA damage is associated with decreased longevity and increased risk for age-related health decline, highlighting the importance of the DNA repair process. Due to its antioxidant potential, pterostilbene offers additional protection for cellular health by reducing oxidative damage, a key contributor to cellular aging. (4)

Enhances Heart Health. Research shows that NR enhances heart health by reducing stiffness of the arteries and supporting healthy blood flow. (5) Aortic stiffness contributes to blood pressure dysregulation and increased cardiac risk, making the reduction of aortic stiffness critical to maintaining heart health. Animal studies also show pterostilbene exhibits cardio-protective effects by reducing oxidative stress of heart tissue. (6)

Protects Against Cognitive Decline. NAD+ is critical to maintaining mitochondrial health of brain cells. A decline of NAD+ levels research suggests that reduced NAD+ levels contribute to many of the hallmarks of brain aging. By increasing NAD+ levels and aiding in the regulation of inflammatory levels, Nicotinamide Riboside shows promise in supporting healthy brain aging and cognitive function. (7) Pterostilbene further supports healthy brain aging by activating sirt-1 and improving synaptic plasticity, a vital biological process related to memory and learning. (8)

References:

1. Fang EF, Lautrup S, Hou Y, et al. NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends Mol Med. 2017;23(10):899-916. doi:10.1016/j.molmed.2017.08.001

2. Grabowska W, Sikora E, Bielak-Zmijewska A. Sirtuins, a promising target in slowing down the ageing process. Biogerontology. 2017;18(4):447-476. doi:10.1007/s10522-017-9685-9

3. Wilk A, Hayat F, Cunningham R, et al. Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity. Sci Rep. 2020;10(1):651. Published 2020 Jan 20. doi:10.1038/s41598-020-57506-9

4. Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects. Molecules. 2022;27(19):6316. Published 2022 Sep 25. doi:10.3390/molecules27196316

5. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9(1):1286. Published 2018 Mar 29. doi:10.1038/s41467-018-03421-7

6. Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S. Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK/Nrf2/HO-1 Pathway in Fructose-Fed Diabetic Rats. Cardiovasc Drugs Ther. 2018;32(2):147-163. doi:10.1007/s10557-018-6780-3

7. Lee HJ, Yang SJ. Supplementation with Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice. Int J Mol Sci. 2019;20(17):4196. Published 2019 Aug 27. doi:10.3390/ijms20174196

8. Michán S, Li Y, Chou MM, et al. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010;30(29):9695-9707. doi:10.1523/JNEUROSCI.0027-10.2010