PE Mouse Anti-Human TIGIT Antibody (S-R730)
SKU: 90734586742

PE Mouse Anti-Human TIGIT Antibody (S-R730)

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Description

PE Mouse Anti-Human TIGIT Antibody (S-R730)Product Specification Host Mouse Antigen TIGIT Synonyms T cell immunoreceptor with Ig and ITIM domains; V set and immunoglobulin domain containing protein 9; V set and transmembrane domain containing protein 3; VSIG9; VSTM3 Location Cell membrane Accession Q495A1 Clone Number S R730 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation PE Physical

Product Specification


Host Mouse
Antigen TIGIT
Synonyms T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3
Location Cell membrane
Accession Q495A1
Clone Number S-R730
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 0.2 mg/ml
Conjugation PE
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

TIGIT (T cell immunoglobulin and ITIM domain) is an inhibitory receptor expressed on lymphocytes, including natural killer (NK) cells and various subsets of T cells such as CD4+ T cells, CD8+ T cells, and regulatory T cells. It was discovered in 2009 through genome-wide analysis aiming to identify proteins containing domain structures typical for immunomodulatory receptors. TIGIT consists of one extracellular immunoglobulin variable domain, a type I transmembrane domain, and a short intracellular domain with one immunoreceptor tyrosine-based inhibitory motif (ITIM) and one immunoglobulin tyrosine tail (ITT)-like motif. Its main ligand is CD155, also known as poliovirus receptor (PVR), but it can also bind to CD112 and CD113 with lower affinity. TIGIT plays a significant role in down-regulating T cell and NK cell functions by interacting with these ligands expressed on antigen-presenting cells or tumor cells. This interaction inhibits immune cell responses at multiple steps of the cancer-immunity cycle, such as impairing T cell priming by dendritic cells, preventing tumor cell killing by NK cells and cytotoxic T cells, and enhancing the immune suppressive activity of regulatory T cells. Therefore, TIGIT has emerged as a major target in cancer immunotherapy. Several monoclonal antibodies that block the inhibitory activity of human TIGIT have been developed, and clinical trials are ongoing to investigate TIGIT blockade as a monotherapy or in combination with anti-PD1/PD-L1 antibodies for the treatment of patients with advanced solid malignancies.

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SKU: 90734586742

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Steve C.
Belleville, US
★★★★★ 5
Buy it you'll love it. You'll realize that you really needed it
Color: Black
Size is perfect for rag, scrubber sponges soap. It's very sturdy love that the block on bottom dryies up all the liquid it's absolutely amazing. It's very convenient, love the way you can organize everything. I'm the kind of person I have to have everything organized that's the way I grew up. I have not seen any signs of rust no where. Highly recommend. It is very very nice.
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Reviewed in the United States on March 3, 2026
B
Verified Purchase
BeaLeti
Fort Morgan, US
★★★★★ 4
Funcional but smaller than I thought
Color: B-silver
I liked it and it replaces something around the kitchen sink that was constantly dripping liquid soap dish into the sink making a mess! This new organizes items much better. It's smaller than I envisioned and wish it came with it's own soap bottles dispensers but I found two small ones placing them side by side and it works. Did not use the metal divider. I cannot tell yet the drying speed of the sliding out stone. It's functional at keeping everything hands reach and organized around the kitchen sink.
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Reviewed in the United States on February 16, 2025
J
Verified Purchase
Janet
Massapequa, US
★★★★★ 5
Very Nice
Color: Black
Really Nice! Its really cute. And it actually does soak up the water and drys fast. I was amazed. Holds just the right amount of things for what you would need. I'm happy with my purchase! ☺️ Nice to get the thing you expected!
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Reviewed in the United States on March 20, 2026
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Carmen C.
Lexington, US
★★★★★ 5
Nice sink caddy
Color: Gold, Color: Gold
It was exactly as described- looks nice on my counter. I haven’t bought the scrub brush I want yet to put in the taller space but it def dries fast anytime water gets on it. I like the look on my counter space. It’s not flimsy, I like the color of the gold.
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Reviewed in the United States on April 30, 2026
M
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Marco A Davila
New York, US
★★★★★ 5
Effective!!
Color: Black, Color: Black
This caddy keeps my sink organized. It absorbs the water when I place my sponges on it and its super easy to keep clean. I squeeze as much waster as I can from the sponges so it doesn't wear out. I've had this a little under a year and it has held up exceptionally well.
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Reviewed in the United States on January 17, 2026

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