Human Reelin Protein, His Tag
SKU: 83585368964

Human Reelin Protein, His Tag

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Description

Human Reelin Protein, His TagProduct Specification Species Human Synonyms RELN Accession P78509 Amino Acid Sequence Protein sequence (P78509, Ser1221 Gln2666, with C His Tag)

Product Specification


Species Human
Synonyms RELN
Accession P78509
Amino Acid Sequence

Protein sequence (P78509, Ser1221-Gln2666, with C-His Tag) SEKQKQIIPVINPTLPQNFYEKPAFDYPMNQMSVWLMLANEGMVKNETFCAATPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAPVLLQYSHDAGMSWFLVKEGCYPASAGKGCEGNSRELSEPTMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYISEPCPSYCSGHGDCISGVCFCDLGYTAAQGTCVSNVPNHNEMFDRFEGKLSPLWYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRTRNEGLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQHGKHSAQWALDDVLIGMNDSSQTGFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSHSVQLQYSLNNGKDWHLVTEECVPPTIGCLHYTESSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVGADSWAIDNVVLASGCPWMCSGRGICDAGRCVCDRGFGGPYCVPVVPLPSILKDDFNGNLHPDLWPEVYGAERGNLNGETIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKSTPERSHSILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFIIDGNNVNNPVMLLDTFDFGPREDNWFFYPGGNIGLYCPYSSKGAPEEDSAMVFVSNEVGEHSITTRDLNVNENTIIQFEINVGCSTDSSSADPVRLEFSRDFGATWHLLLPLCYHSSSHVSSLCSTEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQPVTWAIDNVYIGPQCEEMCNGQGSCINGTKCICDPGYSGPTCKISTKNPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVGRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIGGNISGNTVLEDDFTTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVSTDVAVNEDSFLQIDFAASCSVTDSCYAIELEYSVDLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQPAPFDKQQTWAIDNVYIGDGCIDMCSGHGRCIQGNCVCDEQWGGLYCDDPETSLPTQLKDNFNRAPSSQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPNNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLISGSADQ
Expression System HEK293
Molecular Weight Predicted MW: 163.9 kDa Observed MW: 170 kDa
Purity ＞95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized powder
Storage Buffer

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

Reelin is a large extracellular matrix glycoprotein crucial for brain development and function. During embryonic development, Reelin guides neuronal migration and positioning in the cerebral cortex and hippocampus. It also plays a vital role in the formation of cortical layers and synaptic plasticity. Postnatally, Reelin continues to modulate neurotransmission and memory formation. Dysregulation of Reelin signaling is strongly implicated in several neuropsychiatric disorders, most notably autism, schizophrenia, and bipolar disorder, making it a key protein of interest in neuroscience research for understanding both brain development and the pathophysiology of major mental illnesses.

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Exchange/Return Notes
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SKU: 83585368964

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4.6 ★★★★★
Based on 876 reviews
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Verified Purchase
Taraknits
Alexandria, US
★★★★★ 5
Best. Toy. Ever. For My Superchewer!
Size: Large, Color: Skinny Green, Size: Large, Color: Skinny Green
Best toy ever! My dog destroys toys. Usually within about 15 minutes, she has de-squeakered and defluffed them. By the second day, she has tug-of-war-ed them to shreds. From the time we got this adorable dragon out of the package, she LOVED it. She set to work. It’s been a week, and while she has dewinged him, he lost his squeaker after a few days, and he looks a bit rough, he’s still in one piece! And, we’ve had HOURS of tug-of-war with minimal rips! She’s obsessed 😍 I ordered two more today. We’ve finally found the perfect toy for my baby!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 18, 2026
S
Verified Purchase
SnowshoePete
Louisville, US
★★★★★ 5
My 90 lb. Pitbull's All-Time Fave Toy
Size: Large, Color: Coral, Size: Large, Color: Coral
I ordered a plethora of new toys for Bruce to keep him occupied while I am working remotely from home. Poor guy gets so bored while I'm stuck in front of my computer 8+ hours a day. All the other toys are animated, but this one is just a big floppy chewy squeaky toy. Bruce quickly lost interest in all the other chirping, hopping, and twirling toys and fell in love with "Diny". When I opened Diny and gave it to Bruce, he had the elated and surprised look of a 3 yr old at Christmas. And he stayed that happy for hours, and then each time he picked up Diny to play. Diny became his go-to toy over all others (and there are many!). It is well made out of durable fabric, and they did not stuff it full of kapoc (I hate kapoc in dogs toys!). And it is delightfully low-tech. Normally he tears a squeaky toy apart as soon as he can isolate the squeaky mechanism. But cleverly, the squeaky box is loose in the long belly so it moves from one end to the other as the toy is handled. That made it difficult for Bruce to locate it. The toy remained in good condition for 2 weeks of near constant attention by Bruce. But yesterday he zeroed in on the squeaky box and ripped Diny to shreds. I was sad to see Diny go so soon. But boy-howdy was Bruce happy with it. I'm gonna buy another because we liked it so much. And so did I : )
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 23, 2024
J
Verified Purchase
Jason W
Louisville, US
★★★★★ 5
This is one “under the radar” gem!!
Size: Large, Color: Coral
This is one “under the radar” gem!! Very strong internal squeaker and way tougher than it looks. My big 125lb Shepard-Husky mix gave it heck, then made it his new buddy. He’ll occasionally give it the business but on the whole, it’s surprisingly tough and my big boy loves it. Nice price!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 10, 2026
H
Verified Purchase
H
Whiting, US
★★★★★ 4
Cute but small
Size: Large, Color: Skinny Green
Cute stuffy and has not yet ripped. While my dogs plays with it, the toy is a bit small for him. For reference he is 120lbs.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 27, 2026
J
Verified Purchase
Jenny J
Port Orchard, US
★★★★★ 5
My Puppy Loves this Indestructible Dragon
Size: Large, Color: Pink, Size: Large, Color: Pink
My puppy (8 month old black lab mix) loves, loves, loves her dragon. She has had it for 2 months now. It is one of her favorites and gets daily rough play time. It's her go-to toy for fetch and tug games, as well as just general mouthy play. The squeaker gave out after about 4 weeks, but she would binge squeak for prolonged periods (kind of like chomping on gum) so it was almost a blessing when it went silent. She still chomps on it, but at least now I don't have to hear it. Other than the fact that it's a little grungy and bedraggled from so much loving, it is still in amazing shape. The seams and fur are all still intact. There are no visible holes, rips, or weak spots. I love Chew Guard Technology. This dragon replaced her goDog Iguana (from PetSmart) that developed a tear in the fur after about 4 months of heavy use. (It was superficial, just the outer fur layer and not the innards, but we disposed of it before she could eat more fur.) She can be pretty rough on her toys and I can never predict if any given toy will last minutes or months. The goDog stuffies definitely fall into the "months" category, even with rough daily use. Edit: The dragon lasted about 6 months of intensive, hard play before it developed a small tear in the fur. I patched it a couple times, but once my pup discovers a weak spot, it's the kiss of death for any stuffed item. We had to dispose of the dragon (so sad) to keep her from eating any more of the fur. We replaced the dragon with the goDog Chameleon, which is still going strong. I think we will go back to the dragon for our next toy because it's just so darned cute. We gave the dragon to my niece for her golden retriever puppy who is very chew-happy. That dragon is also doing well. You've just gotta love that chew-guard technology. This is one tough toy.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 26, 2015

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