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Description
Nectin-4 His Tag Protein, RatProduct Specification Species Rat Synonyms PRR4LNIRNectin cell adhesion molecule 4PVRL4Ig superfamily receptor LNIRPoliovirus receptor related protein 4NECTIN4Poliovirus Receptor Related 4Nectin 4Nectin 4EDSS1 Accession D3ZET1 Amino Acid Sequence Tyr28 Val348, with C terminal His Expression System HEK293 Molecular Weight 40 42kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized
Product Specification
| Species | Rat |
| Synonyms | PRR4，LNIR，Nectin cell adhesion molecule 4，PVRL4，Ig superfamily receptor LNIR，Poliovirus receptor-related protein 4，NECTIN4，Poliovirus Receptor-Related 4，Nectin-4，Nectin 4，EDSS1 |
| Accession | D3ZET1 |
| Amino Acid Sequence | Tyr28-Val348, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 40-42kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Reymond, N. et al. (2001) J. Biol. Chem. 276:43205. 2.Takai, Y. et al. (2008) Nat. Rev. Mol. Cell Biol. 9:603. 3.Fabre, S. et al. (2002) J. Biol. Chem. 277:27006. |
Background
Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectin extracellular domains (ECDs) contain three Ig-like domains: an N-terminal V-type that mediates ligand binding, and two C2-type .Human Nectin-4 is normally expressed in the placenta, especially in endothelial cells, while in the mouse it is found in the embryo, lung, testis and brain. In humans, mutation of Nectin-4 has been correlated with ectodermal dysplasia-syndactyly syndrome,High Nectin-4/PVRL4 expression was associated with poor-prognosis in some invasive breast cancers and may be a new promising prognostic biomarker and specific therapeutic target.
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