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Description
CD300b/LMIR5/CD300LB Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD300b Protein, Human; CLM 7 Protein, Human; CLM7 Protein, Human; CMRF35 A2 Protein, Human; IREM 3 Protein, Human; IREM3 Protein, Human; TREM 5 Protein, Human; TREM5 Protein, Human Accession Q3U497 Amino Acid Sequence Ile18 Tyr157, with C hIgG Fc Expression System HEK293 Molecular Weight 52 64kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Physical Appearance Lyophilized
Product Specification
| Species | Mouse |
| Synonyms | CD300b Protein, Human; CLM-7 Protein, Human; CLM7 Protein, Human; CMRF35-A2 Protein, Human; IREM-3 Protein, Human; IREM3 Protein, Human; TREM-5 Protein, Human; TREM5 Protein, Human |
| Accession | Q3U497 |
| Amino Acid Sequence | Ile18-Tyr157, with C-hIgG Fc |
| Expression System | HEK293 |
| Molecular Weight | 52-64kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Journal List Cell Death Differ v.21(11); 2014 Nov PMC4211373. |
Background
The CD300 receptor family members are a group of molecules that modulate a variety of immune cell processes. The CD300 receptor family consists of members with activating and inhibitory capabilities mainly expressed on the surface of immune cells. LMIR5, also known as CD300b, CD300LB, CLM-7, and IREM-3, is a glycoprotein member of the immunoglobulin superfamily. Human LMIR5 consists of a 134 amino acid (aa) extracellular domain (ECD) with one Ig-like V-type domain, a 21 amino acid (aa) transmembrane segment, and a 29 aa cytoplasmic domain. Studies have shown that CD300b recognizes PS as a ligand and regulates phagocytosis of apoptotic cells through DAP12 signaling pathway.
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4.3 ★★★★★
Based on 467 reviews
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Product Reviews
★★★★★ 5
Surprisingly Durable, Very Soft, and All of My Dogs Immediately Loved It
Color: Green
I honestly expected this to be just another cute plush squeaky toy that would last maybe a day or two in a house with multiple dogs, especially larger breeds, but I was pleasantly surprised by how well this one has held up so far.
The fabric is very soft without feeling overly thin or cheaply stuffed, and the toy arrived fully intact with no strange chemical smell right out of the packaging, which I always appreciate when buying toys for dogs that immediately put everything in their mouths. The stitching also looked much better than many inexpensive plush toys I’ve purchased in the past.
All of my dogs immediately gravitated toward it — from my Dobermans to my smaller dogs — which honestly says a lot because they can be very selective about textures and squeakers. The squeaker itself is loud enough to keep their attention without being one of those painfully obnoxious high-pitched squeaks that make you regret purchasing the toy five minutes later.
I also appreciate that the fabric is soft enough for indoor play and carrying around the house without feeling overly rough or stiff the way some “durable” dog toys can feel. It has held up surprisingly well to daily tossing, carrying, squeaking, and general chaos so far.
For the price, I actually think this is a very good value, especially if you have multiple dogs or dogs that enjoy plush comfort toys but still like squeakers and interactive play. It arrived quickly, packaged well, and looked exactly like the listing photos upon arrival.
Very happy overall and would absolutely purchase additional styles again.
#FoundItOnAmazon #AmazonFinds #DogMom #DobermanMom #DogToys #PetSupplies #DogLife #LargeBreedDogs #SmallDogs #DogLovers #PetLifestyle #EverydayFavorites #LuxeLife
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Reviewed in the United States on May 11, 2026
★★★★★ 5
Good quality. Excellent price
Color: Green
Very durable and lots of fun!
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Reviewed in the United States on May 4, 2026
★★★★★ 4
Fun toy but not as durable as I hoped.
Color: Green
I just rescued a dog from the shelter. She is super sweet and playful but she loves to chew her toys so I needed to buy her ones more durable to play with. This toy caught my eye but I was concerned that it might be too large for my small 7 pound terrier mix. After receiving it, I really loved the colors and the way it looked and my dog loves playing with it. Everything about it is great except that within a few weeks of playing with it, she already managed to make a small tear in it. It's not to the point where I would take it away from her toy box but I just wish it was more durable.
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Reviewed in the United States on November 8, 2025
★★★★★ 5
Great for tug of war
Color: Green
All the arms make for a good tug of war toy. It’s tough enough that my 70 lbs lab can pull on it and it’s fine
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Reviewed in the United States on May 30, 2026
★★★★★ 5
Durable
Color: Green, Color: Green
We’ve had it for awhile now and it’s still (mostly) in one piece. Has held up well for our heavy chewing puppy. It lost a tentacle but that’s nothing compared to the level of destruction our dog has put other toys through in much shorter amounts of time. Recommend for heavy chewers and will likely buy again!
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Reviewed in the United States on February 24, 2026
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