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Description
Activin receptor type 1 (ACVR1) Recombinant Rabbit mAb (S-2058-256)Product Specification Host Rabbit Antigen Activin receptor type 1 (ACVR1) Synonyms Activin receptor type 1; Activin receptor type I (ACTR I); Activin receptor like kinase 2 (ALK 2); Serine threonine protein kinase receptor R1 (SKR1); TGF B superfamily receptor type I (TSR I); ACVRLK2 Immunogen Synthetic Peptide Location Membrane Accession Q04771 Clone Number S 2058 256 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk
Product Specification
| Host | Rabbit |
| Antigen | Activin receptor type 1 (ACVR1) |
| Synonyms | Activin receptor type-1; Activin receptor type I (ACTR-I); Activin receptor-like kinase 2 (ALK-2); Serine/threonine-protein kinase receptor R1 (SKR1); TGF-B superfamily receptor type I (TSR-I); ACVRLK2 |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | Q04771 |
| Clone Number | S-2058-256 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Predicted Reactivity | Bv, Ck |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu, Ms, Rt, Mk |
Background
Activin receptor type 1 (ACVR1, also known as ALK-2) is a bone morphogenetic protein (BMP) type I serine/threonine kinase receptor of the TGF-β superfamily that, upon ligand binding and phosphorylation by cognate type II receptors, propagates signals by phosphorylating SMAD1/5/8 transcription factors to orchestrate embryonic patterning, skeletal development, and postnatal tissue repair, while pathogenic gain-of-function mutations (e.g., R206H) drive the rare congenital disorder fibrodysplasia ossificans progressiva through aberrant chondro-osseous differentiation and also contribute to the oncogenesis of diffuse intrinsic pontine glioma by hyperactivating the BMP–SMAD axis .
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